Microencapsulated Porcine Islets for Sustained Insulin and Therapeutic Delivery

Type 1 diabetes--when a human's body is unable to produce sufficient insulin to regulate blood sugar levels--impacts millions of people worldwide, including nearly 2 million people in the US alone. The advent of insulin injections a centuray ago to treat type 1 diabetics transformed the disease from a virtual death sentence to a manageable medical condition. More than 100 years after the first treatment of a type 1 diabetic with insulin, however, people suffering from type 1 diabetes still must administer daily injections in order to manage their disease. 

Minimally-invasive, long-term blood sugar control would transform the lives of people suffering from Type I diabetes, who currently manage their disease through constant insulin monitoring, a specialized diet, and daily injections. Researchers from the University of Illinois Urbana-Champaign have developed a technology that enables such treatment. Their approach uses a system of microcapsules and microspheres to introduce and sustain insulin-producing porcine pancreatic islets within a patient for weeks or more. 

Benefits

  • Long-term blood sugar control  
  • Could reduce or eliminate need for insulin injections

Publication

Lew, B., Kim, IY., Choi, H. et al. Sustained exenatide delivery via intracapsular microspheres for improved survival and function of microencapsulated porcine islets.Drug Deliv. and Transl. Res. 8, 857–862 (2018). https://doi.org/10.1007/s13346-018-0484-x