RT-PCR RNA based approaches, the most popular method for SARS-CoV-2 detection, are limited by large numbers of consumables and reagents required, the need for well-optimized protocols, challenges with mutations, and RNA lingering after infectivity. Researchers at the University of Illinois, led by Dr. Aaron Timperman, have developed a protein-based rapid, reliable and inexpensive nanofluidic/microfluidic system to detect viral proteins with limits of detection at clinically relevant levels. The system receives a sample, purifies the virions, prepares the sample and sprays the sample directly into a mass spectrometry. This protein-based approach allows the collection of additional information such sequence mutations, modifications that affect protein function, and bound antibodies.