Researchers have developed a method that accelerates data acquisition for Fourier transform-ion cyclotron resonance (FT-ICR) mass spectrometry imaging (MSI) by ten folds while maintaining high mass and spatial resolution and accuracy. Compared to other methods in MSI data acquisition/reconstruction, this approach exploits redundancy in the data, eventually reducing the time for data collection. The primary applications of the technology will be in clinical diagnostics, drug metabolism studies and localization/characterization of biomolecules within tissue samples.