Dr. Kimani Toussaint and Mr. Chukwuemeka Okoro have developed a Second-harmonic Patterned Polarization-Analyzed Reflection Confocal (SPPARC) microscopy technique combining confocal microscopy, second harmonic generation (SHG) microscopy and Mueller matrix polarimetry. SPPARC has a strong potential to more accurately and quantitatively describe 3D microstructural changes in collagen-rich samples as well as non-collagenous extra-fibrillary matrix regions. It also provides a framework for 3D label-free SHG-patterned quantification of collagen to more accurately monitor sensitive changes. For more information, please contact the Office of Technology Management at otm@illinois.edu.